In Use Case 3, a coupled signalling-hemodynamic model for the simulation of​ hyperdynamic circulation will be developed to enable a more effective prevention and treatment of portal hypertension and its severe complications. This model will be applied to the TIPS intervention (Transjugular intrahepatic Portosystemic shunt placement, one of the mainstay treatment options), to assist the prediction of patients at higher risk of post-intervention heart failure (HF).