Use Case 2 – Fibrosis-associated heart failure patients

Use Case 2 will explore the use of experimental and clinical data in combination with mathematical modelling approaches to improve risk stratification of cardiovascular disease (CVD) in MASLD patients at various stages. These patients are uniquely affected by cardiovascular disease – ranging from atherosclerotic disease, hypertension and arrhythmias to myocardial infarction, strokes and heart failure. Those affected are a vulnerable group that poses a huge challenge in everyday clinical practice. Our goal is to utilize multimodal data ranging from laboratory parameters to imaging data and multiOMICs characterization for integrative mathematical modelling approaches, to identify patients at high risk for adverse cardiovascular events or outcomes and eventually optimize their clinical care.

Additionally, Use Case 2 is interwoven with Use Case 1 – which assesses the trajectory of liver fibrosis – that can be mirrored in cardiac fibrosis.